The on-line in vivo analysis of bioactive molecules at the living animal level could reflect the chemical information change in real life process. Thus it is significant in the research of analytical chemistry and neuropathology. The Prof. Lanqun Mao’s group in ACL embarks on the research of new mechanisms and methods of analytical chemistry for living biosystems all the time. Recently, their systematic research achievements on electroanalysis chemistry awarded the first class of Science and Technology Awards of Beijing.