HOME INTRODUCTION STAFF RESEARCH RECRUITMENT CONTACT US 中文
  • 5号楼-2.jpg
  • banner_01.jpg
Location:Home > Insight on research
Insight on research
wang1.jpg  
Research in the Laboratory Revealed That Transferrin Can Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells
Human transferrins (hTf) are a family of single-chain glycoproteins, working as the iron transporter in blood. Cancer cells often require a high level of iron(III) in order to facilitate rapid cell growth and thereby express a high level of the hTf receptors (hTfR). The heterometal-transferrin complexes, such as ruthenium(III), gallium(III), indium(III), and titanium(IV) complexes, are still recognized by TfR, and can be thus transported to cells via TfR-mediated endocytosis. Accordingly, the...
  2 Page(s)   FirstPrev12
 
  Copyright © CAS Key Laboratory of Analytical Chemistry for Living Biosystems
Zhongguancun North First Street 2,100190 Beijing, PR China