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Novel molecularly imprinted materials for highly-selective analysis of complex samples
Molecularly imprinted polymer (MIP), an artificial recognition material with high affinity and selectivity to the template molecule, has attracted more and more attention in the fields of chromatography, artificial antibodies, chemical sensors, and drug delivery. To address challenging problems of molecularly imprinted technology such as imprinting biological macromolecules, template leakage, low binding efficiency, and incompatibility with aqueous media, Prof. Rui ZHAO’s group in CAS Key La...
Research of the Laboratory Advanced the Design and Synthesis of Metal-based Multi-targeting Antitumor Complexes
Malignant tumor is one of the most dangerous fatal diseases to human being. Molecular targeting anticancer drugs have attracted an increasing attention for their high selectivity and low toxicity. The researchers in Wang’s Group of the CAS Key Laboratory of Analytical Chemistry for Living Biosystems have designed and synthesized a series of organic protein kinase inhibitors which contain potential sites for metal coordination (Eur. J. Med. Chem. 2013, 61, 84–94; Bioorg. Med. Chem. Lett. 201...
Research in the Laboratory Revealed That Transferrin Can Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells
Human transferrins (hTf) are a family of single-chain glycoproteins, working as the iron transporter in blood. Cancer cells often require a high level of iron(III) in order to facilitate rapid cell growth and thereby express a high level of the hTf receptors (hTfR). The heterometal-transferrin complexes, such as ruthenium(III), gallium(III), indium(III), and titanium(IV) complexes, are still recognized by TfR, and can be thus transported to cells via TfR-mediated endocytosis. Accordingly, the...
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