Prof Qun Luo----CAS Key Laboratory of Analytical Chemistry for Living Biosystems

Dr Qun Luo, Associate Professor

Date of Birth: Apr, 1970.

Tel: 010-62529069

Mobil: 13520735629

Email: qunluo@iccas.ac.cn

Professional Qualifications

l Member of the Chinese Society of Chemistry.

Selective Publications

L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486.

Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *, F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555.

W. Zeng, Y. Zhang, W. Zheng, Q. Luo, J. Han, J. Liu, Y. Zhao, F. Jia, K. Wu*, and F. Wang*, Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry, Molecules, 2019, 24, 1852.

J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584.

W. Zeng, Z. Du, Q. Luo, Y. Zhao, Y. Wang, K. Wu, F. Jia, Y. Zhang,* F. Wang*, Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA, Anal. Chem. 2019, 91, 6035-6042. Y. Zhang, Q. Luo, W. Zheng,* Z. Y. Wang, Y. Lin, E. L. Zhang, S. Lü, J. F. Xiang, Y. and F. Y. Wang*, Luminescent cyclometallated platinum(II) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents, Inorg. Chem. Front. 2018, 5, 413-424.

S. Y. Liu, W. Zheng, K. Wu,* Y. Lin, F. F. Jia, Y. Zhang, Z. Y. Wang, Q. Luo, Y. Zhao, F. Y. Wang* Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex, Chem. Commum. 2017, 53, 4136-4139.

Y. Y. Wang, Z. F. Du,* W. Zheng, K. Wu, D. C. Xu, Q. Luo, Y. Zhao, J. J. Han, Y. Z. Liu, F. Y. Wang,* Deciphering of Interactions between Platinated DNA and HMGB1 by Hydrogen/Deuterium Exchange Mass Spectrometry, Dalton Trans. 2017, 46, 6133-6484.

K. Wu, F. F. Jia, W. Zheng, Q. Luo, Y. Zhao, F. Y. Wang,* Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging, J. Biol. Inorg. Chem. 2017, 22, 653-661.

W. Zheng, Y. Zhao*, Q. Luo, Y. Zhang, K. Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249.

J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605.

L. J. Li, W. Guo, K. Wu,* X. L. Wu, L. H. Zhao, Y. Zhao, Q. Luo, Y. Y. Wang, Y. Z. Liu, Q. W. Zhang, F. Y. Wang,* A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106.

J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.

Y. Zhang, W. Zheng,* Q. Luo, Y. Zhao, E. L. Zhang, S. Y. Liu, F. Y. Wang,* Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands, Dalton Trans. 2015, 44, 13100–131.

S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c.

G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417.

Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan, F.-Y. Wang*, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951.

L. Y. Ji, W. Zheng, Y. Lin, X. L. Wang, S. Lü, X. Hao, Q. Luo,* X. C. Li, L. Yang, F. Y. Wang,* Novel Ruthenium Complexes Ligated with 4-Anilinoquinazoline Derivatives: Synthesis, Characterisation and Preliminary Evaluation of Biological Activity, Eur. J. Med. Chem. 2014, 77, 110-120

W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang, F.-Y. Wang*, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun. 2013, 49, 10224-10226.

K. Wu, S. Liu, Q. Luo, W. Hu, X. Li, F.-Y, Wang*, R. Zheng, J. Cui, P. J. Sadler, J. Xiang, Q. Shi, S. Xiong, Thymines in Single-Stranded Oligonucleotides and G-Quadruplex DNA Are Competitive with Guanines for Binding to an Organoruthenium Anticancer Complex, Inorg. Chem. 2013, 52 (19), 11332-11342.

Y. Lin, Y-D Huang, W. Zheng, F.-Y. Wang*, A. Habtemariam, Q. Luo, X.-C. Li, K. Wu, P. J. Sadler, S.-X. Xiong, Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π, J Inorganic Biochem, 2013, 128, 77-84

W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong, F.-Y. Wang,^* Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem. 2013, 52, 5328-5338.

K. Wu, W. Hu, Q. Luo, X. Li, S. Xiong, P. Sadler, F.-Y. Wang*, Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down, J. Am. Soc. Mass. Spectrom., 2013, 24, 410-420.

Qun Luo, Jianhua Cao, Daihua Tang*, Dayong Wu,Yong Huang, Junfeng Xiang, Fuyi Wang*, Xinhou Liu, Gang Wu* Lipophilic thioguanosine: an anion receptor for cesium fluoride，Journal of Fluorine Chemistry，published online（DOI: http://dx.doi.org/doi:10.1016/j.jfluchem.2013.02.020）

S. Lü, W. Zheng, L. Ji, Q. Luo*, X. Hao, X. Li, F.-Y. Wang*, Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors, Eur. J. Med. Chem. 2013, 61, 84-94.

Wenbing Hu, Jianan Liu, Qun Luo*，Yumiao Han, Kui Wu, Shuang Lv, Shaoxiang Xiong, and Fuyi Wang*,. Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to β-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation, Rapid Commun. Mass Spectrom., 2011, 25, 1429-1436.

Qun Luo，Dayong Wu, Shixiong Liu, Daihua Tang, Yong Huang, Xinhou Liu, Fuyi Wang, Ruiyao Wang, and Gang Wu. The formation of thymidine-based T-tetramers with remarkable structural and metal ion size effects. Organic & Biomolecular Chemistry, 2011, 9, 1030-1033

Qun Luo, Daihua Tang, Gang Wu. Ribose-protected Thioguanosine-based 1H . NMR Spectroscopic Probe for the Detection of Cesium from Solid Cesium-containing Sources in Acetonitrile. Inorganic Chemistry Communications, 2008, 11 ，1359–1362．

Qun Luo, Daihua Tang, Xiaodong Li, Qi Wang, Zhipeng Wang, Zhen Zhen, and Xinhou Liu. Preparation of Polysilsesquioxane (CH3SiO1.5)8 Crystals from Swollen PHEMA. Chemistry Letters, 2006, 35(3), 278-279.

Qun Luo, Daihua Tang, Zhen Zhen, and Xinhou Liu. 2’-Deoxy-3’,5’-di-O-acetyl-uridine Acta Crystallographica Section E, 2007.63 (1) .o4－o6.