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Prof. Fuyi Wang

 

Group Leader: Prof Dr Fuyi Wang

Date of Birth: Feb, 1964.

Tel: 010-62529069

Email: fuyi.wang@iccas.ac.cn

 Education and Work Experience

1983.6:               BSc., Central China Normal University

1991.6:               MSc., Central China Normal University

1999.7:               Ph.D., Wuhan University

1991 – 1997       Lecturer, Analysis Center, Central China Normal University

1997 – 1999:       Associate professor, Analysis Center, Central China Normal University

2000 – 2002:      Royal Society (UK) Research Fellow, University of Edinburgh

2002 – 2007:      Research Associate, University of Edinburgh

2007 – now     Hundred Talent Program Professor, Institute of Chemistry, CAS

 

Professional Qualifications

Executive Member of the Chinese Society for Mass Spectrometry

Associate Member of the Chinese Human Proteome Organisation

 

Selective Publications

  • S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c

  • G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417

  • L. Y. Ji, W. Zheng, Y. Lin, X. L. Wang, S. , X. Hao, Q. Luo,* X. C. Li, L. Yang, F. Y. Wang,* Novel Ruthenium Complexes Ligated with 4-Anilinoquinazoline Derivatives: Synthesis, Characterisation and Preliminary Evaluation of Biological Activity, Eur. J. Med. Chem. 2014, 77, 110-120

  • Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan, F.-Y. Wang*, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951. 

  • Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637. 

  • W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang, F.-Y. Wang*, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun. 2013, 49, 10224-10226. 

  • K. Wu, S. Liu, Q. Luo, W. Hu, X. Li, F.-Y, Wang*, R. Zheng, J. Cui, P. J. Sadler, J. Xiang, Q. Shi, S. Xiong, Thymines in Single-Stranded Oligonucleotides and G-Quadruplex DNA Are Competitive with Guanines for Binding to an Organoruthenium Anticancer Complex, Inorg. Chem. 2013, 52 (19), 11332-11342
  • Y. Lin, Y-D Huang, W. Zheng, F.-Y. Wang*, A. Habtemariam, Q. Luo, X.-C. Li, K. Wu, P. J. Sadler, S.-X. Xiong, Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π, J Inorganic Biochem, 2013, 128, 77-84
  • W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong, F.-Y. Wang,* Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem. 2013, 52, 5328-5338.
  • K. Wu, W. Hu, Q. Luo, X. Li, S. Xiong, P. Sadler, F.-Y. Wang,* Competitive binding sites of a ruthenium arene anticancer complex on oligonucleotides studied by mass spectrometry: ladder-sequencing vs top-down, J. Am. Soc. Mass. Spectrom., 2013, 24, 410-420.

     S. Lü, W. Zheng, L. Ji, Q. Luo, X. Hao, X. Li, F.-Y. Wang,* Synthesis, characterization, screening and docking analysis of 4-anilinoquinazoline derivatives as tyrosine kinase inhibitors, Eur. J. Med. Chem. 2013, 61, 84-94.

     L. Ji, J.-H. Wu, Q. Luo, X. Li, W. Zheng, G. Zhai, F.-Y. Wang,* S. Lü, Y.-Q. Feng*, J. Liu, S. Xiong, Quantitative Mass Spectrometry Combined with Separation and Enrichment of Phosphopeptides by Titania Coated Magnetic Mesoporous Silica Microspheres for Screening of Protein Kinase Inhibitors, Anal. Chem. 2012, 84, 2284-2291.

     K. Wu, Q. Luo, W. Hu, X. Li, F.-Y. Wang,* S. Xiong, P. J. Sadler,* Mechanism of Interstrand Migration of Organoruthenium Anticancer Complexes within a DNA Duplex, Metallomics, 2012, 4, 136-148.

     Y. M. Han, Q. Luo, X. Hao, X. C. Li, F.-Y. Wang,* W. B. Hu, K. Wu, S. Lü, P. J. Sadler,* Reactions of an organoruthenium anticancer complex with 2-mercaptobenzanilide - a model for the active-site cysteine of protein tyrosine phosphatase 1B, Dalton Trans. 2011, 40, 11519-11529

     W.B. Hu, Q. Luo, K. Wu, X.C. Li, F.-Y. Wang,* Y. Chen, X.Y. Ma, J.P. Wang, J.A. Liu, S.X. Xiong, P.J. Sadler,* The anticancer drug cisplatin can cross-link the interdomain zinc site on human albumin, Chem. Commun. 2011, 47, 6006–6008.

     W. B. Hu, J. A. Liu, Q. Luo,* Y. M. Han, K. Wu, S. Lv, S. X. Xiong, F.-Y. Wang,* Elucidation of the Binding Sites of Sodium Dodecyl Sulfate to b-Lactoglobulin Using Hydrogen/Deuterium Exchange Mass Spectrometry Combined with Docking Simulation, Rapid Commun. Mass Spectrom. 2011, 25, 1429-1436.

     Lv, Q. Luo, X. C. Li, K. Wu, J. A. Liu, S. X. Xiong, Y.Q. Feng, F.-Y. Wang,* Inhibitor Screening of Protein Kinases Using MALDI-TOF MS Combined with Separation and Enrichment of Phosphopeptides by TiO2 Nanoparticle Deposited Capillary Column, Analyst, 2010, 135, 2858-2863.

     W. B. Hu, Q. Luo, X. Y. Ma, K. Wu, J. A. Liu, Y. Chen, S. X. Xiong, J. P. Wang, P. J. Sadler, F.-Y. Wang,* Arene control over thiolate to sulfinate oxidation in albumin by organometallic ruthenium anticancer complexes, Chem. Eru. J. 2009, 15, 6586-6594

     F.-Y. Wang,* A. Habtemariam, E. P. L. van der Geer, R. J. Deeth, R. Gould, S. Parsons, P. J. Sadler,* synthesis, Characterization and reaction pathway for the formation of a GMP adduct of a cytotoxic thiocyanato ruthenium arene complex, J. Biol. Inorg. Chem., 2009, 14, 1065-1076

     F.-Y. Wang, S. Weidt, J. Xu, C. L. Mackay, P. R. R. Langridge-Smith, P. J. Sadler,* Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with 18O-labeling, J. Am. Soc. Mass Spectrom. 2008, 19, 544-549

     F.-Y. Wang, A. Habtemariam, E. P. L. van der Geer, R. Fernández, M. Melchart, R. J. Deeth, R. Aird, S. Guichard, F. P. A. Fabbiani, P. Lozano-Casal, I. D. H. Oswald, D. I. Jodrell, S. Parsons, P. J. Sadler,* Controlling ligand substitution reactions of organometallic complexes: tuning cancer cell cytotoxicity, Proc. Natl. Acad. Sci. USA. 2005, 102, 18269-18274.

     F.-Y. Wang, J. Xu, A. Habtemariam, J. Bella, P. J. Sadler,* Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex: detection of a sulfenato intermediate. J. Am. Chem. Soc. 2005, 127, 17734-17743.

     F.-Y Wang, H. M. Chen, S. Parsons, I. D. H. Oswald, J. E. Davidson, P. J. Sadler,* Kinetics of aquation and anation of ruthenium(II) arene anticancer complexes, acidity and X-ray structures of aqua adducts. Chem. Eur. J. 2003, 9, 5810-5820.

     F.-Y. Wang, H. M. Chen, J. A. Parkinson, P. D. Murdoch, P. J. Sadler,* Reactions of a ruthenium(II) arene antitumor complex with cysteine and methionine. Inorg. Chem. 2002, 41, 4509-4523.

     

    For more publications by Wang group, please click “Publications”.

     

    Current Research Projects

    1.       2012.1-2016.12, NSFC National Major Research Project on Scientific Instruments: High resolution and multi-functional chemical imaging system (21127901), 8.7 million CNY

    2.       2012.1-2016.12, NSFC Key ProjectMethodology for investigations on interactions between regulating protein and DNA damaged by drug (21135006), 3 million CNY

    3.       2011.1-2013.12, NSFC Major International Cooperation Project: Methodology for interactromics of metal-based anticancer agents (21020102039)2.6 million CNY

    4.       2010.1-2012.12, NSFC General Project: Investigation of interactions between organometallic ruthenium anticancer complexes and serum proteins (20975103), 0.35 million CNY

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