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Prof. Fuyi Wang


Group Leader: Prof Dr Fuyi Wang

Date of Birth: Feb, 1964.

Tel: 010-62529069

Email: fuyi.wang@iccas.ac.cn

 Education and Work Experience

1983.6:               BSc., Central China Normal University

1991.6:               MSc., Central China Normal University

1999.7:               Ph.D., Wuhan University

1991 – 1997       Lecturer, Analysis Center, Central China Normal University

1997 – 1999:      Associate professor, Analysis Center, Central China Normal University

2000 – 2002:      Royal Society (UK) Research Fellow, University of Edinburgh

2002 – 2007:      Research Associate, University of Edinburgh

2007 – now    Professor, Institute of Chemistry, CAS


Professional Qualifications

Executive Member of the Chinese Society for Mass Spectrometry

Associate Member of the Chinese Human Proteome Organisation


Selective Publications


  • Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *,  F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555. 
  • W. Zeng, Y. Zhang, W. Zheng, Q. Luo, J. Han, J. Liu, Y. Zhao, F. Jia, K. Wu*, and F. Wang*, Discovery of Cisplatin Binding to Thymine and Cytosine on a Single-stranded Oligodeoxynucleotide by High Resolution FT-ICR Mass Spectrometry, Molecules, 2019, 24, 1852.
  • L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486.
  • Y. Zhang, W. Zeng, L. Huang, W. Liu, E. Jia, Y. Zhao, F. Wang*, Z. Zhu*, In Situ Liquid Secondary Ion Mass Spectrometry: A Surprisingly Soft Ionization Process for Investigation of Halide Ion Hydration, Anal. Chem. 2019, 91, 7039-7046.
  • W. Zeng, Z. Du, Q. Luo, Y. Zhao, Y. Wang, K. Wu, F. Jia, Y. Zhang,* F. Wang*, Proteomic Strategy for Identification of Proteins Responding to Cisplatin-Damaged DNA, Anal. Chem. 2019, 91, 6035-6042.
  • Y. Zhang, J.G. Wang, X. Yu, D. R. Baer, Y. Zhao, L. Mao, F. Wang,* Z. Zhu*, Potential-Dynamic Surface Chemistry Controls the Electrocatalytic Processes of Ethanol Oxidation on Gold Surfaces, ACS Energy Lett. 2019, 4, 215-221.
  • J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584.
  • Y. Y. Zhang, M. Su, X. F. Yu, Y. F. Zhou, J. G. Wang, R. G. Cao, W. Xu, C. M. Wang, D. R. Baer, O. Borodin, K. Xu, Y. T. Wang, X. L. Wang, Z, J. Xu, F. Y. Wang* and Z. H. Zhu*Investigation of Ion-Solvent Interactions in Nonaqueous Electrolytes Using in Situ Liquid SIMS, Anal. Chem. 2018, 90, 3341-3348.
  • Y. Zhang, Q. Luo, W. Zheng,* Z. Y. Wang, Y. Lin, E. L. Zhang, S. Lü, J. F. Xiang, Y. and F. Y. Wang*, Luminescent cyclometallated platinum(II) complexes: highly promising EGFR/DNA probes and dual-targeting anticancer agents, Inorg. Chem. Front. 2018, 5, 413-424.
  •  Y. Y. Cheng, W. J. Zeng, Y. Cheng, J. S. Zhang, T. Zou, K. Wu* and F. Y. Wang*, Selective binding of an organoruthenium complex to G-rich human telomeric sequence by tandem mass spectrometry, Rapid Commun. Mass Spectrom. 2018, 32, 2152-2158.

  • Z. Y. Wang, Y. Y. Zhang, B. W. Liu, K. Wu, S. Thevuthasan, D. R. Baer, Z. H. Zhu,* X. Y. Yu* and F. Y. Wang*, In situ Mass Spectrometric Monitoring of the Dynamic Electrochemical Process at the Electrode-Electrolyte Interface: a SIMS Approach, Anal. Chem. 2017, 89, 960-965.
  • S. Y. Liu, W. Zheng, K. Wu,* Y. Lin, F. F. Jia, Y. Zhang, Z. Y. Wang, Q. Luo, Y. Zhao, F. Y. Wang* Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex, Chem. Commum. 2017, 53, 4136-4139.
  • Y. L. Jin, Y. F. Xie, K. Wu, Y. Y. Huang,* F. Y. Wang,* R. Zhao,* Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor, ACS Appl. Mater. Interfaces 2017, 9, 8490-8497.
  • Y. Y. Wang, Z. F. Du,* W.  Zheng, K. Wu, D. C. Xu, Q. Luo, Y.  Zhao, J. J. Han, Y. Z. Liu, F. Y. Wang,* Deciphering of Interactions between Platinated DNA and HMGB1 by Hydrogen/Deuterium Exchange Mass Spectrometry, Dalton Trans. 2017, 46, 6133-6484.
  • K. Wu,  F. F. Jia, W. Zheng, Q. Luo, Y. Zhao, F. Y. Wang,* Visualization of metallodrugs in single cells by secondary ion mass spectrometry imaging, J. Biol. Inorg. Chem. 2017, 22, 653-661.
  • W. Zheng, Y. Zhao*, Q. Luo, Y.  Zhang, K.  Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249.
  • J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605.
  • L. J. Li, W. Guo, K. Wu,* X. L. Wu, L. H. Zhao, Y. Zhao, Q. Luo, Y. Y. Wang, Y. Z. Liu, Q. W. Zhang, F. Y. Wang,* A comparative study on the interactions of human copper chaperone Cox17 with anticancer organoruthenium(II) complexes and cisplatin by mass spectrometry, J. Inorg. Biochem., 2016, 161, 99-106.

  • Z. Y. Wang, J. Liu, Y. F.  Zhou J. J. Neeway, D. K. Schreiber, J. V. Crum, J. V. Ryan, X. L. Wang, F. Y. Wang,* Z. H. Zhu,* Nanoscale imaging of Li and B in nuclear waste glass, a comparison of ToF-SIMS, NanoSIMS, and APT, Surf. Interface Anal. 2016, 48, 1392-1401.

  • J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.

  • Y. Zhang, W. Zheng,* Q. Luo, Y. Zhao, E. L. Zhang, S. Y. Liu, F. Y.  Wang,* Dual-targeting organometallic ruthenium(II) anticancer complexes bearing EGFR-inhibiting 4-anilinoquinazoline ligands, Dalton Trans. 2015, 44, 13100–131.

  • Z. Y. Wang, B. W. Liu, E. W. Zhao, K. Jin, Y. G. Du, J. J. Neeway, J. V. Ryan, D. H. Hu, K. H. L. Zhang, M. Hong, S. Le Guernic, S. Thevuthasan, F. Y. Wang,* Z. H.  Zhu*, Argon Cluster Sputtering Source for ToF-SIMS Depth Profiling of Insulating Materials: High Sputter Rate and Accurate Interfacial Information, , J. Am. Soc. Mass Spectrom., 2015, 26, 1283-1290

  • S. Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c.
  • G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417.
  • Z. Du, Q. Luo, L. Yang, T. Bing, X. Li, W. Guo, K. Wu, Y. Zhao, S. Xiong, D. Shangguan, F.-Y. Wang*, Mass Spectrometric Proteomics Reveals that Nuclear Protein Positive Cofactor PC4 Selectively Binds to Cross-Linked DNA by a trans-Platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951.


  • Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637.



    For more publications by Wang group, please click “Publications”.

    Current Research Projects

  • 2020.1 – 2024.12, NSFC National Major Research Project on Scientific Instruments:High resolution in situ liquid SIMS system (21927804),8 million CNY 

  • 2016.1 – 2019.12, NSFC General Project: Methodology for investigations on the molecular mechanisms of metal antitumor drugs on the basis of chemical genetics (21575145), 0.78 million CNY

  • 2013.1 – 2017.12,National Key Basic Research Development Program (973 Program) Project: the theoretical research about the nature of TCM based on the efficacy of alleviating water retention (2013CB531805),4.20 million CNY

  • 2012.1-2016.12, NSFC National Major Research Project on Scientific Instruments: High resolution and multi-functional chemical imaging system (21127901), 8.7 million CNY

  • 2012.1-2016.12, NSFC Key ProjectMethodology for investigations on interactions between regulating protein and DNA damaged by drug (21135006), 3 million CNY

  • 2011.1-2013.12, NSFC Major International Cooperation Project: Methodology for interactromics of metal-based anticancer agents (21020102039)2.6 million CNY

  • 2010.1-2012.12, NSFC General Project: Investigation of interactions between organometallic ruthenium anticancer complexes and serum proteins (20975103), 0.35 million CNY

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