Study and research experience

2001.9~2005.6    B.S.      Chemistry, Nanjing University, P. R. China

2005.9~2008.6    M.S.     Chemistry, Nanjing University, P. R. China

2008.9~2012.6    PhD      Chemistry, University of Warwick, UK

Selected publication

• L. Qi, Q. Luo, Y. Zhang, F. Jia, Y. Zhao*, F. Wang*, Advances in Toxicological Research of the Anticancer Drug Cisplatin, Chem. Res. Toxicol. 2019, 32(8), 1469-1486.

• Y. Lin, J. Wang, W. Zheng, Q. Luo, K. Wu, J. Du,* Y. Zhao *,  F. Wang*, Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue, Metallomics, 2019, 11, 546-555. 

• Yumiao Han, Wei Guo, Wei Zheng, Qun Luo, Kui Wu, Yao Zhao^*, Fuyi Wang, Mass spectrometric quantification of the binding ratio of metal-based anticancer complexes with protein thiols, Rapid Commun Mass Spectrom. 2019; 33, 951–958.

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  J. Du, Y. Y. Wei, Y. Zhao*, F. M. Xu, Y. Y. Wang, W. Zheng, Q. Luo, M. Wang and F. Y. Wang,* A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin-Thioredoxin Reductase System Activity by Induced Oxidization of the Protein, Inorg. Chem. 2018, 57, 5575-5584.

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  C. F. Shao, Y. Zhao* K. Wu, F. F. Jia, Q. Luo, Z. Liu*and F. Y. Wang, Correlated Secondary Ion Mass Spectrometry-Laser Scanning Confocal Microscopy Imaging for Single Cell-Principles and Applications, Chinese J. Anal. Chem. 2018, 46, 1005-1016.

• W. Zheng, Y. Zhao,* Q. Luo, Y. Zhang, K. Wu and F. Y. Wang,* Multi-Targeted Anticancer Agents (invited review), Current Topics in Medicinal Chemistry, 2017, 17, 3084-3098

• J. Du, Y. Kang, Y. Zhao,* W. Zheng, Y. Zhang, Yu Lin, Z. Y. Wang, Y. Y. Wang, Q. Luo, Kui Wu, and F. Y. Wang,* Synthesis, Characterization, and in Vitro Antitumor Activity of Ruthenium(II) Polypyridyl Complexes Tethering EGFR-Inhibiting 4-Anilinoquinazolines, Inorg. Chem., 2016, 55, 4595-4605.

• W. Zheng, Y. Zhao*, Q. Luo, Y.  Zhang, K.  Wu, F. Y. Wang*, Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes, Sci China Chem, 2016, 59(10), 1240-1249.  

• J. Du, E. L. Zhang, Y. Zhao,* W. Zheng, Y. Zhang, Y. Lin, Z. Y. Wang, Q. Luo, K. Wu, F. Y. Wang*, Dscovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells, Metallomics, 2015, 7, 1573-1583.

• S.Y. Liu, K. Wu,* W. Zheng, Y. Zhao, Q. Luo, S. X. Xiong, F. Y. Wang,* Identification and Discrimination of Binding Sites of an Organoruthenium Anticancer Complex to Single-Stranded Oligonucleotides by Mass Spectrometry, Anlayst, 2014, 10.1039/c4an00807c

• G. J. Zhai, X. Y. Wu, Q. Luo, K. Wu, Y. Zhao, Y. L. Min, J. A. Liu, X. S. Xiong, Y. Q. Feng, L. P. Yang,* F. Y. Wang,* Absolute Quantification of Serum Phosphopeptides by Mass Spectrometry Coupled to Titania Coated Magnetic Mesoporous Silica Microsphere Enrichment, Talanta, 2014, 125, 411–417

• Z. F. Du, Q. Luo, L. P. Yang, T. Bing, X. C. Li, W. Guo, K. Wu, Y. Zhao, S. X. Xiong, D. H. Shangguan, F. Y. Wang,* Mass Spectrometric Proteomics Reveals that Nuclear Protein Posi-tive Cofactor PC4 Selectively Binds to Crosslinked DNA by a Trans-platinum Anticancer Complex, J. Am. Chem. Soc. 2014, 136, 2948-2951

• W. Zheng, Q. Luo, Y. Lin, Y. Zhao, X. Wang, Z. Du, X. Hao, Y. Yu, S. Lu, L. Ji, X. Li, L. Yang, F.-Y. Wang*, Complexation with organometallic ruthenium pharmacophores enhances the ability of 4-anilinoquinazolines inducing apoptosis, Chem. Commun. 2013, 49, 10224-10226.

• W. Guo, W. Zheng, Q. Luo, X. Li, Y. Zhao, S. Xiong, F.-Y. Wang,^* Transferrin Serves As a Mediator to Deliver Organometallic Ruthenium(II) Anticancer Complexes into Cells, Inorg. Chem. 2013, 52, 5328-5338.

• Y. Zhao, N. J. Farrer, H. Li, J. S. Butler, R. J. McQuitty, A. Habtemariam, F.-Y. Wang*, P. J. Sadler*, De Novo Generation of Singlet Oxygen and Ammine Ligands by Photoactivation of a Platinum Anticancer Complex, Angew. Chem. Int. Ed. 2013, 52, 13633-13637.  

• Zhao, Y; Woods, J. A. Farrer, N. J.; Robinson, K. S.; Pracharova, J.; Kasparkova, J.; Novakova, O.; Li, H.; Salassa, L.; Pizarro, A. M.; Clarkson, G. J.; Song, L,; Brabec, V.; Sadler, P. J.^*; Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts, Chem. Eur. J, 2013, 19, 9578-959

•  Zhao, Y.; Roberts, G. M.; Greenough, S. E.; Farrer, N. J.; Paterson, M. J.; Powell, W. H.; Stavros, V. G.; Sadler, P. J.^*, Two-photon-activated ligand exchange in platinum(II) complexes. Angew. Chem. Int. Ed. 2012, 51 (45), 11263-11266.

• Tai, H.-C.^#; Zhao, Y.#; (^#, equal contribution) Farrer, N. J.; Anastasi, A. E.; Clarkson, G.; Sadler, P. J.^*; Deeth, R. J.^*, A computational approach to tuning the photochemistry of platinum(IV) anticancer agents, Chem. Eur. J, 2012, 18 (34), 10630-10642.

• Li, H.; Wells, S. A.; Jimenez-Roldan, J. E.; R？mer, R. A.; Zhao, Y.; Sadler, P. J.; O'Connor, P. B.^*, Protein flexibility is key to cisplatin crosslinking in calmodulin. Protein Sci. 2012, 21 (9), 1269-1279.

•  Li, H.; Lin, T.-Y.; Van Orden, S. L.; Zhao, Y.; Barrow, M. P.; Pizarro, A. M.; Qi, Y.; Sadler, P. J.; O’Connor, P. B.^*, Use of Top-Down and Bottom-Up Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Mapping Calmodulin Sites Modified by Platinum Anticancer Drugs. Anal. Chem. 2011, 83 (24), 9507-9515.

•  Li, H.; Zhao, Y.; Phillips, H. I. A.; Qi, Y.; Lin, T.-Y.; Sadler, P. J.; O’Connor, P. B.^*, Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent. Anal. Chem. 2011, 83 (13), 5369-5376.

•  Farrer, N. J.; Woods, J. A.; Salassa, L.; Zhao, Y.; Robinson, K. S.; Clarkson, G.; Mackay, F. S.; Sadler, P. J.^*, A Potent Trans-Diimine Platinum Anticancer Complex Photoactivated by Visible Light. Angew. Chem. Int. Ed. 2010, 49 (47), 8905-8908.

• Kan, X.; Geng, Z.; Zhao, Y.; Wang, Z.^*; Zhu, J.-J.^*, Magnetic molecularly imprinted polymer for aspirin recognition and controlled release. Nanotechnology 2009, 20 (16), 165601.

• Kan, X. W.; Zhao, Y.; Geng, Z. R.; Zhu, J. J.^*; Wang, Z. L.^*, Composites of multiwalled carbon nanotubes and molecularly imprinted polymers for dopamine recognition. J. Phys. Chem. C 2008, 112 (13), 4849-4854.